When I think of the best pizza I've ever had, I think of two places: Pizzeria Baffetto in Rome and Serious Pie. It's that good.
Quinn's in Capitol Hill was our first gastropub in Seattle, and the food is just amazing. Their burger made it on USA Today's list of the 10 best burgers in the country, and rightfully so -- but seriously, you cannot go wrong with anything on their menu.
Speaking of burgers, there's Lunchbox Laboratory. It's a short drive from downtown up to Ballard and well worth it. It's run by a former high-end chef making what he loves, and it has a cult following. Think of incredibly customizable gourmet burgers cooked and served in something barely more than a shack, with friendly people and kitschy decor, and you're getting the idea.