Be careful with the Galt House.
The Galt House is right on the river, and bills itself as a "four star" hotel. The reality is a bit different. It has two towers, one of which is four star accommodations (the east), one of which is two star accommodations (the west). The staff is about right for a three star hotel. If you can't guarantee you're in the east tower I'd pass; but if you can it has a great view of the river, and is centrally located. It also does a huge convention business, with lots of space of its own and a connection to the convention center. Great for a convention, woe to anyone unlucky enough to meet 200 people who just got out of an event wanting the same elevator.