if you don't have $600 to blow on dinner @ Alinea or Moto, but still want a taste of Chicago's molecular gastronomics, head to Otom - same kitchen as Moto, and right next door - but 1/10th the price for a scaled down 'comfort food' version of quixotic cuisine. Fantastic drinks too, the old bar-chef is now at Violet Hour. I'd say try Schwa but they're horrible to actually get seated at; odd hours and no reservations.
if want 'normal' food (as in not prepared with liquid nitrogen or vaporized) - then try Avec, or their new 'Publican'.
all are fantastic & cannot go wrong with anything on the menu.
This tip has the address "moto - 945 W Fulton Market"