Plastic is one of the oldest club in Milan, and still one of the craziest and coolest. On Thursday the crowd is quite young. I personally love it on Friday (check you for the "Plastic London Night" on myspace to get in the list, or you might not accepted at the door). Saturnday the crowd is mainly homosexual. Get there at 11pm if you want to make sure to get in. Real action starts from 1 am, though.
Usually it's quite difficult to find tickets to see the Last Supper of Leonardo da Vinci. An alternative way is to take a guided tour, with agencies that book tickets in advance and can help you appreciate the masterwork. One of the agencies is Leonardo a Milano, www.leonardoamilano.org
It's always full on a Sunday night full of Italian families. What else can I say? Food is excellent and quite reasonable and the Risotto Milanese is fabulous but what do you expect in Milano. Right near the Sheraton Diana Hotel, it's conveniently near Porta Venezia, at Via Sirtori 26.
A fantastic pizza restaurant: cool interior, great people and exquisite food. I had a calzone with panchetta, cheese and basil that was magnificent. It's right around the corner from one of the most popular and vibrant neighborhoods for evening adventures.
I noticed that in Milan there are lots of coffee shops, but not gourmet restaurants, only pasta, pizza, lots of wheat, but no fish, fresh greens, and all this fuzz, i believe it might be the nature of this city